Brenner Longevity Model – Executive Gold DPC Summary Core Thesis: Longevity is not the avoidance of death, but preservation of repair capacity, physiologic reserve, function, identity, and autonomy until late life, with compression of morbidity and deliberate preparedness.

1. Biochemical Foundations (Upstream Control) • Insulin resistance (HOMA IR): earliest accelerator of vascular disease, cancer risk, cognitive decline, and frailty. • Glycation & cross linking: sugars bind amino acids → AGEs → stiff vessels, joints, lenses, enzymes. • Mitochondria & NAD : declining NAD impairs ATP, DNA repair enzymes, and sirtuins. • DNA damage & senescence: SASP drives inflammaging. • mTOR > autophagy: damaged proteins accumulate.

2. Evidence Anchored Interventions • Omega 3 (EPA/DHA). • Metformin (selected adults). • Vitamin D if deficient. • Senolytics: emerging. • Avoid: excess refined carbs, tobacco, chronic over nutrition, unnecessary meds.

3. Function & Organ Systems • MSK: grip, gait, chair rise, floor to stand; fix joints early. • Vision: night driving, contrast, cataracts, glaucoma. • Hearing: speech in noise difficulty. • Dental: periodontal disease, bite strength. • Skin: routine derm surveillance.

4. Lifestyle as Biology • Exercise: resistance + aerobic. • Sleep: identify & treat OSA. • Social connection: medical necessity.

5. Standard Prevention • Vaccinations. • Colonoscopy & cancer screening. • BP, lipids, metabolic review.

6. Preparedness (Because Success Shortens Dying) • Wills, trusts, POA, healthcare proxy. • Financial & digital access (incl. international). • Cultural & burial preferences. Goal: Shift patients into the functional longevity cohort with dignity, autonomy, and minimal suffering.

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Longevity & Performance Medicine

 

Live longer. Live stronger. Live intentionally.

At Andover Internal Medicine, longevity is not simply avoiding disease — it is a structured plan to optimize metabolism, preserve mobility, protect the brain, and build the physical and hormonal resilience required for a high-quality life over decades.

 

This is a medical program designed for adults who want more than “annual labs.”

This is proactive medicine.

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What This Program Includes

 

1. Metabolic Optimization

  • Weight loss strategy (nutrition, GLP-1 options, metabolic resistance reversal)

  • Visceral fat reduction

  • Insulin sensitivity improvement

  • Muscle-preserving weight loss for adults over 40

  • Lipid optimization

  • ApoB and advanced cholesterol profiling

2. Longevity Diagnostics

 

A deeper look at the systems that determine long-term health:

  • Comprehensive metabolic panel

  • Full endocrine panel (thyroid, adrenal, testosterone/estradiol when indicated)

  • Cardiovascular risk panel

  • High-sensitivity CRP

  • Ferritin, B12, folate

  • Omega-3 index (optional)

  • Sleep evaluation

  • DEXA (optional local referral)

  • Full spirometry + FeNO for inflammatory lung disease

  • GI inflammatory and functional testing

3. Cardiovascular Protection

  • EKG interpretation

  • Coronary risk stratification

  • BNP, D-dimer when indicated

  • Cardiac inflammation markers

  • Blood pressure pattern analysis

  • Medication optimization where needed

4. Strength, Mobility & Fall-Resistance Training

 

Aging is determined more by muscle loss than any other factor.

 

Your program includes:

  • Personalized strength-training plan

  • Sarcopenia evaluation

  • Balance & fall-risk testing

  • Joint preservation strategy

  • Posture & mobility assessment

 

This is your ability-to-live-independently plan, starting decades before most physicians address it.

5. Respiratory Longevity

  • Full spirometry

  • FeNO airway inflammation testing

  • Viral vs bacterial pulmonary differentiation

  • Asthma/COPD optimization

6. Brain Longevity Protection

  • Sleep quality evaluation

  • Cognitive screening baseline

  • Inflammation & metabolic risk reduction

  • Personalized plan to reduce vascular dementia risk

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Program Structure

 

You may choose one of the following:

 

Standard Longevity Package

  • Quarterly visits

  • Longevity labs 1–2× per year

  • Strength & mobility plan

  • Medication optimization

  • Sleep & metabolic evaluation

 

Executive Longevity Package

 

Designed for high-performing individuals whose professional or personal responsibilities require them to stay at their best - and who expect healthcare that provides clarity, precision, and time for comprehensive care

 

Includes everything above PLUS:

  • Monthly performance coaching

  • Hormonal assessment

  • Annual full-body MRI (separate pricing)

  • Advanced diagnostics

  • Personalized metabolic & strength program

  • Coordination with specialists including periodontists, ophthalmologists, and audiologists

  • Priority access

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Pricing

 Pricing that complements the existing membership structure:

  • Standard Longevity Add-On (members): $75–$125/month

  • Comprehensive Longevity Add-On (members): $195–$295/month

  • Non-members: more expensive (e.g., $395 consult + $200–$400/month)

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Call to Action

 

Begin your Longevity Plan

DNA Repair

Aging accelerates when damage outpaces repair. Longevity is the preservation of repair capacity